Detailed Bupropion dosage information for adults. Includes dosages for Depression, Depression and Smoking Cessation; plus renal, liver and dialysis adjustments. Bupropion is an antidepressant medication used to treat major depressive disorder and seasonal affective disorder. The Zyban brand of bupropion is used to help people stop smoking by reducing cravings and other withdrawal effects. Generic Name: Bupropion HCL (byoo-PROE-pee-on) Drug Class: Antidepressant, Miscellaneous Table of Contents Overview How to Take It Side Effects Warnings & You may be interested in natural options to treat your depression. Some people use these treatments instead of drugs, and some use them as an add-on treatment to their antidepressant medication. A list of depression medications (antidepressants). The following are some of the depression medications (antidepressants) available in the U.S.: Recent Examples on the Web: Adjective. In interviews, dozens of people who had experienced antidepressant withdrawal recounted similar stories: The drugs often relieved mood problems, at first. Bupropion, sold under the brand names Wellbutrin and Zyban among others, is a medication primarily used to treat major depressive disorder and to support stopping smoking. It is an effective antidepressant on its own, but is also used as an add-on medication in cases of incomplete response to first-line SSRI antidepressants. Bupropion (Aplenzin, Wellbutrin, Wellbutrin SR, Wellbutrin XL) is used to treat depression. Bupropion (Aplenzin, Wellbutrin XL) is also used to treat seasonal affective disorder (SAD; episodes of depression that occur at the same time each year [usually in the fall and winter but rarely may occur in the spring or summer months]). Antidepressants are a class of drugs that reduce symptoms of depressive disorders by correcting chemical imbalances of neurotransmitters in the brain. Wellbutrin (Bupropion) is an antidepressant medication used for treating depression and seasonal affective disorder (SAD).